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Bruce Wilson
Hey George:
Most all of us men are destined for it.
I agree that PSA should still be used. I go to UCSD Med Ctr. and they have stopped recommending PSA tests, but it is left as an option for the person to request.
There is an even more powerful combined test developed in Michigan. The last I heard it was only offered at UMICH and has to be requested by your doctor.
PCA3 test - science details here http://www.nature.com/pcan/journal/v16/n2/full/pcan20134a.html
Less scientific discussion here: http://www.nytimes.com/2013/03/27/business/new-prostate-cancer-tests-may-supplement-psa-testing.html?pagewanted=all&_r=0
New Prostate Cancer Tests Could Reduce False Alarms
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A b s t r a c t
ERG rearrangements (most commonly
transmembrane protease, serine 2 [TMPRSS2]:ERG
[T2:ERG] gene fusions) have been identified in
approximately 50% of prostate cancers . Quantification
of T2:ERG in postdigital rectal examination urine, in
combination with PCA3, improves the performance
of serum prostate-specific antigen for prostate cancer
prediction on biopsy. Here we compared urine
T2:ERG and PCA3 scores with ERG+ (determined
with immunohistochemical analysis) and total
prostate cancer burden in 41 mapped prostatectomies.
Prostatectomies had a median of 3 tumor foci (range,
1-15) and 2.6 cm of summed linear tumor dimension
(range, 0.6-7.1 cm). Urine T2:ERG score correlated
most with summed linear ERG+ tumor dimension and
number of ERG+ foci (rs = 0.68 and 0.67, respectively,
both P < .001). Urine PCA3 score showed weaker
correlation with both number of tumor foci (rs =
0.34, P = .03) and summed linear tumor dimension
(rs = 0.26, P = .10). In summary, we demonstrate a
strong correlation between urine T2:ERG score and
total ERG+ prostate cancer burden at prostatectomy,
consistent with high tumor specificity.
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Vitamin D3 supplementation has a large number of beneficial effects, including apparently impacting prostate cancer. The combination of low dose aspirin (83mg) and vitamin D3 is even more beneficial.
I'd suggest getting your serum D3 measured.
The results of this clinical study suggest that supplementation with vitamin D3 at 4000IU per day may benefit patients with early stage, low-risk prostate cancer on active surveillance, because of the improved outcome (a decreased number of positive cores at repeat biopsy) in more than half of the subjects enrolled in the trial.
http://www.ncbi.nlm.nih.gov/pubmed/23220550
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